Orthobiologics in Muscle Injury

Muscle injuries are a frequent concern in competitive athletes and military personnel, often hindering their ability to continue in their sport or service. Due to the significant impact of these injuries and the urgency of returning to activity, orthobiologics such as prolotherapy, platelet-rich plasma, and mesenchymal stem cells have been explored as treatment options aimed at promoting tissue regeneration through immunomodulation toward tissue regeneration. However, despite growing interest and numerous preclinical studies, high-level clinical evidence supporting the efficacy of these treatments remains lacking, underscoring the need for further research.