Efficacy of hypertonic dextrose injection (prolotherapy) in temporomandibular joint dysfunction: a systematic review and meta-analysis

tmj Scientific reports 2021 · PMID 34282199

Hypertonic dextrose prolotherapy (DPT) has been reported to be effective for temporomandibular disorders (TMDs) in clinical trials but its overall efficacy is uncertain. To conduct a systematic review with meta-analysis of randomized controlled trials (RCTs) to synthesize evidence on the effectiveness of DPT for TMDs. Eleven electronic databases were searched from their inception to October, 2020. The primary outcome of interest was pain intensity. Secondary outcomes included maximum inter-incisal mouth opening (MIO) and disability score. Studies were graded by "Cochrane risk of bias 2" tool; if data could be pooled, a meta-analysis was performed. Ten RCTs (n = 336) with some to high risk of bias were included. In a meta-analysis of 5 RCTs, DPT was significantly superior to placebo injections in reducing TMJ pain at 12 weeks, with moderate effect size and low heterogeneity (Standardized Mean Difference: - 0.76; 95% CI - 1.19 to - 0.32, I2 = 0%). No statistically significant differences were detected for changes in MIO and functional scores. In this systematic review and meta-analysis, evidence from low to moderate quality studies show that DPT conferred a large positive effect which met criteria for clinical relevance in the treatment of TMJ pain, compared with placebo injections.Protocol registration at PROSPERO: CRD42020214305.

bu makaleden üretilen sorular (5)

tmj orta

Literaturde en sik kullanilan dekstroz konsantrasyonlarini gozden geciriyorsunuz.

Sit ve ark. meta-analizine gore TMJ proloterapisinde en sik uygulanan dekstroz konsantrasyonlari hangileridir?

cevabı gör

doğru cevap: %25, %17 ve %12.5

açıklama: Sit ve ark. (Sci Rep 2021;11:14638): literaturde dekstroz konsantrasyonlari %10-30 arasindadir ve en sik %25, %17 ve %12.5 uygulanir.

Sit RW, Reeves KD, Zhong CC, et al. Efficacy of hypertonic dextrose injection (prolotherapy) in TMJ dysfunction: systematic review and meta-analysis. Sci Rep 2021;11:14638 PMID 34282199

tmj orta

%12.5 dekstroz ile tedavi planlarken optimum seans sayisini belirliyorsunuz.

Sit ve ark. meta-analizinde %12.5 dekstroz icin onerilen optimum tedavi seans sayisi kactir?

cevabı gör

doğru cevap: 4 seans

açıklama: Sit ve ark. (Sci Rep 2021): %12.5 konsantrasyon icin dort seansin optimum tedavi sayisi oldugu one surulmustur.

Sit RW, Reeves KD, Zhong CC, et al. Efficacy of hypertonic dextrose injection (prolotherapy) in TMJ dysfunction: systematic review and meta-analysis. Sci Rep 2021;11:14638 PMID 34282199

tmj orta

TMD hastasina proloterapinin agri disi sonuclar uzerindeki etkisini aciklayacaksiniz.

Sit ve ark. meta-analizinde dekstroz proloterapisi 12. haftada hangi sonucu saglar?

cevabı gör

doğru cevap: TMJ agrisini plaseboya gore anlamli azaltir (SMD -0.76) ancak maksimum agiz acikligi acisindan plasebodan ustun degildir

açıklama: Sit ve ark. (Sci Rep 2021;11:14638): 10 RKC/336 hastada 12. haftada agri SMD -0.76 ile plaseboya gore anlamli azalir, ancak maksimum agiz acikligi acisindan plasebodan ustun degildir.

Sit RW, Reeves KD, Zhong CC, et al. Sci Rep 2021;11:14638 PMID 34282199

tmj kolay

Literaturdeki dekstroz konsantrasyon araligini ozetliyorsunuz.

Sit ve ark. meta-analizine gore TMJ proloterapisinde kullanilan dekstroz konsantrasyon araligi nedir?

cevabı gör

doğru cevap: %10-30

açıklama: Sit ve ark. (Sci Rep 2021;11:14638): kullanilan dekstroz konsantrasyonlari %10-30 arasinda olup en sik %25, %17 ve %12.5 uygulanir.

Sit RW, Reeves KD, Zhong CC, et al. Efficacy of hypertonic dextrose injection (prolotherapy) in TMJ dysfunction: systematic review and meta-analysis. Sci Rep 2021;11:14638 PMID 34282199

tmj kolay

Sit meta-analizinin buyuklugunu belirtiyorsunuz.

Sit ve ark. meta-analizinde agri sonucu kac RKC ve kac hasta uzerinden hesaplanmistir?

cevabı gör

doğru cevap: 10 RKC, 336 hasta

açıklama: Sit ve ark. (Sci Rep 2021;11:14638): 10 RKC ve 336 hasta uzerinden 12. haftada agri SMD -0.76 hesaplanmistir.

Sit RW, Reeves KD, Zhong CC, et al. Sci Rep 2021;11:14638 PMID 34282199

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